Ethanol → HCID 88543298, compound

Participants

Reaction Conditions

Reaction Steps

1,1-dimethylethyl 3-[(methyloxy)methyl]-4-oxo-1-piperidinecarboxylate D31 (1.2 g) and hydroxylamine hydrochloride (410 mg, 4.9 mmol) were dissolved in ethanol (60 ml). The reaction mixture was heated to 78° C. for 4 hours. Solvent was removed and dichloromethane (excess) was added. The organic layer was washed with water (3×), brine, collected and solvent removed to afford a yellow oil of the desired product D32 in 1.3 g. LCMS [M-56+H] 217.1@ 1.68 min (5 min run)

Provenance & Evidence