Potassium Iodide → HCID 10538587, compound

Participants

Reaction Steps

A solution of 1-(2-chloroethyl)pyrrolidine D36 (9.2 g) and methyl 3-hydroxybenzoate (12.5 g, 82 mmol) and potassium iodide (13.68 g, 82 mmol) and potassium carbonate (11.37 g, 82 mmol) in acetone (200 ml) was refluxed for 2 days. The reaction was filtered and concentrated to give crude product which was purified by chromatography on silica gel eluting with pet eth/EtOAc 5/1 and EtOAc and MeOH to give 1.6 g of desired product D37 as a brown product. LCMS [MH+] 250.1 g 1.53 min (5 min run)

Provenance & Evidence