Potassium Carbonate → HCID 86710211, compound

Participants

Reaction Steps

4-chloro-1H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile D42 (60 mg) and potassium carbonate (282 mg, 2.04 mmol) were dissolved in DMF (6 ml), {2-[(chloromethyl)oxy]ethyl}(trimethyl)silane (69 mg, 0.41 mmol) was added dropwise. The reaction mixture was stirred at R.T. for 16 hours. The reaction mixture was poured onto water (30 ml), extracted with EtOAc (60 ml). Organic layer was washed with water (3×20 ml), brine (20 ml), dried (Na2SO4), filtered and concentrated in vacuo to obtain a yellow oil of desired product D43 in 105 mg. LCMS [MH+] [email protected] min (5 min run)

Provenance & Evidence