1,2-Dibromoethane → Ethyl 3-(2-bromoethoxy)benzoate

Participants

Reaction Conditions

Reaction Steps

To a solution of ethyl 3-hydroxybenzoate D45 (5 g) and K2CO3 (12.48 g, 90 mmol) in Acetonitrile (150 mL) stirred under nitrogen was added 1,2-dibromoethane (33.9 g, 181 mmol). The reaction mixture was stirred at 60° C. overnight. The reaction mixture was filtered, concentrated to give the crude as clear oil. The crude was purified to give the expected product D46 in 4.2 g, eluting with Petroleum oil/EtOAc=3/1. LCMS Retention time=1.76 mins, [M+H]+273 (5 min run)

Provenance & Evidence