Potassium Carbonate → HCID 86710213, compound

Participants

Reaction Steps

To a suspension of (2R)-2-methylpyrrolidine (300 mg, 3.52 mmol) and potassium carbonate (974 mg, 7.05 mmol) in Acetonitrile (20 mL) stirred at room temperature was added ethyl 3-[(2-bromoethyl)oxy]benzoate D46 (962 mg). The reaction mixture was stirred at 80° C. for 24 hours. After cooled to room temperature the mixture was filtrated and the filtrate was concentrated. The crude product was added to a silica gel column and was eluted with Hexane/EtOAc/TEA in ratio 50/50/0.5. The relevant fractions were isolated and solvent evaporated to afford the title compound D50 in 900 mg as a yellow oil. LCMS Retention time=1.09 mins, [M+H]+278 (5 min run)

Provenance & Evidence