Hydrochloric Acid → HCID 67974870, compound

Participants

Reaction Steps

To the material of ethyl 3-({2-[(3R)-3-fluoro-1-pyrrolidinyl]ethyl}oxy)benzoate D48 (220 mg) was added HCl (0.3 ml, 9.87 mmol) at room temperature. The reaction was stirred at 100° for 2.5 hours. The mixture was concentrated in vacuo. To the residue was added 5 ml of ether and stirred 0.5 hours, filtered and the filtrate was evaporated in vacuo to give the expected product D52 in 160 mg. LCMS Retention time=0.90 mins, [M+H]+254 (5 min run)

Provenance & Evidence