Water → HCID 178480103, compound

Participants

Reaction Steps

N-{1-[5-(1-methyl-1H-pyrazol-4-yl)-7-(phenylsulfonyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-4-piperidinyl}benzamide D27 (160 mg) and cesium carbonate (285 mg, 0.88 mmol) in MeOH (2 ml) and THF (4 ml) was stirred under nitrogen at room temperature for 1 hour. EtOAc was added followed by water and the aqueous layer was extracted with EtOAc. The combined extracts were washed with brine, dried over MgSO4 and concentrated to give crude product. This was purified by TLC preparation eluting with EtOAc to give 50 mg of desired product E40. LCMS [MH+] [email protected] min (5 min run)

Provenance & Evidence