Sodium Methoxide → HCID 178522293, compound

Participants

Reaction Conditions

Reaction Steps

N-{1-[5-chloro-7-(phenylsulfonyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-4-piperidinyl}benzamide D41 (240 mg) and sodium methoxide (157 mg, 2.9 mmol) were dissolved in MeOH (15 ml). The reaction mixture was heated at 75° C. for 30 min and then extracted with EtOAc (150 ml); washed with water (60 ml), brine (2×60 ml). Yellow oil obtained, solvent removed to afford a yellow solid which was purified by prep HPLC (mobile phase: A: 0.01% NH4HCO3/H2O B; ACN. Column shimazu PRC-ODS 10.0 uM, 20×250 mm. Method 07.8 min 40-50% ACN 8-10 min 95˜95% ACN. Flow rate 30 mL/min to give product E44 as an ashen solid in 73 mg. LCMS [MH+] [email protected] min (5 min run)

Provenance & Evidence