1,2-Dichloroethane → HCID 86710215, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 3-({2-[(2R)-2-methyl-1-pyrrolidinyl]ethyl}oxy)benzoic acid D54 (116 mg), HOBT (119 mg, 0.778 mmol) and EDC (149 mg, 0.778 mmol) in Dichloromethane (DCM) (15 mL) stirred at 25° C. was added a solution of 1-(5-methyl-1H-pyrrolo[2,3-d]pyrimidin-4-yl)-4-piperidinamine D11a (90 mg, 0.389 mmol) and DIEA (201 mg, 1.556 mmol) in N-Methyl-2-pyrrolidone (NMP) (5 mL). The reaction mixture was stirred at 25° C. overnight. Then the mixture was washed with water (30 ml) and the organic layer was separated. The aqueous layer was extracted with DCM (20 ml×2) and the combined organic layer was concentrated.

Provenance & Evidence