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HRID2168274

反应详情

EQUATION

反应方程式

HRID 2168274 的结构方程式

REACTANTS

反应物

2
结构：C[C@H]1C[C@H]2CON[C@@]2(c2cccc(C#N)c2)CO1
HCID86721299

未命名化合物

结构：C[C@H]1C[C@@H](CO)[C@](N)(c2cc(C#N)ccc2Cl)CO1
HCID86721300

未命名化合物

PRODUCTS

生成物

1
结构：C[C@H]1C[C@@H](CO)[C@](N)(c2cccc(C#N)c2)CO1
HCID86721298

未命名化合物

PROCEDURE

实验过程

3-[(3aR,5S,7aS)-5-Methyltetrahydro-1H-pyrano[3,4-c][1,2]oxazol-7a(7H)-yl]benzonitrile (C21) was converted to the product using the method described for the synthesis of 3-[(3S,4R,6S)-3-amino-4-(hydroxymethyl)-6-methyltetrahydro-2H-pyran-3-yl]-4-chlorobenzonitrile (C18) in Example 6. The resulting product was used in the next step without further purification. Yield: 105 mg, 0.426 mmol, 60%. LCMS m/z 247.1 [M+H+].

WORKUP

后处理

  1. customThe resulting product was used in the next step without further purification