HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetonitrile → 2-(5-Bromo-2-fluorophenyl)-2-((trimethylsilyl)oxy)acetonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetonitrile | HCID 6342 | — |
| Reactant | Trimethylsilyl cyanide | HCID 82115 | — |
| Reactant | 5-Bromo-2-fluorobenzaldehyde | HCID 736327 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Product | 2-(5-Bromo-2-fluorophenyl)-2-((trimethylsilyl)oxy)acetonitrile | HCID 58197564 | — |
Reaction Steps
To a solution of 5-bromo-2-fluorobenzaldehyde (3.4160 g, 16.8 mmol) and DMAP (0.0256 g, 0.21 mmol, 0.012 equiv) in CH3CN (35 mL) was added TMSCN (1.8885 g, 19.0 mmol, 1.13 equiv) dropwise via a syringe under nitrogen at room temperature. After 3.75 h, the solvent was removed under reduced pressure. The crude product was directly used in the next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09045500B2 |
| Source dataset | uspto-grants-2015_06 |
| ORD ID | ord-ff3d80e6396e466494df53a16a430b87 |
| Source note | uspto-grants-2015_06 |