HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzyl Bromide → HCID 67144510, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzyl Bromide | HCID 7498 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | [5-Fluoro-2-(methoxycarbonyl)phenyl]boronic acid | HCID 4374269 | — |
| Catalyst | Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+) | HCID 178418228 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 67144510 | HCID 67144510 | — |
Reaction Steps
5-Fluoro-2-(methoxycarbonyl)phenylboronic acid (1.00 g), benzyl bromide (0.50 mL), K2CO3 (1.75 g), and [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II) (PdCl2(dppf)) (0.17 g) were stirred in tetrahydrofuran (20 mL) at 60° C. for 24 hours. The reaction mixture was chromatographed on silica gel with 2% ethyl acetate/hexanes.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09045420B2 |
| Source dataset | uspto-grants-2015_06 |
| ORD ID | ord-d962aa4cb6da46d0a130af5f489a9985 |
| Source note | uspto-grants-2015_06 |