HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2168342Generated: October 26, 2026
4-Chloro-3-nitrobenzenesulfonamide → HCID 67169936, compound
https://huagongshe.com/reaction/2168342
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 4-Chloro-3-nitrobenzenesulfonamide | HCID 7324 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 1,4-Dioxane | HCID 31275 | — |
| Reactant | 1-(2,2,2-Trifluoroethyl)piperidin-4-amine hydrochloride | HCID 17840002 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 67169936 | HCID 67169936 | — |
Reaction Steps
4-chloro-3-nitrobenzenesulfonamide (1.300 g), 1-(2,2,2-trifluoroethyl)piperidin-4-amine hydrochloride (1.201 g), and triethylamine (2.30 mL) were added to 1,4-dioxane (50 mL) and water (5 mL) and heated at 90° C. for 16 hours. The solution was concentrated on vacuum and purified by flash column chromatography on silica gel with ethyl acetate increasing to 5% methanol in ethyl acetate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09045420B2 |
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| Source dataset | uspto-grants-2015_06 |
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| ORD ID | ord-e648c994e76348a0aac2a3178a357626 |
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| Source note | uspto-grants-2015_06 |
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