HCID 70896225, compound → HCID 70896224, compound

Participants

Reaction Steps

(S)-4-chloro-7-(quinuclidin-3-yl)-8,9-dihydro-[1,4]diazepino[6,7,1-hi]indazol-6(7H)-one (428 mg, 1.30 mmol) from Step F above was dissolved in 1.25 M HCl in CH3OH and concentrated under reduced pressure. The resulting yellow-green solid was triturated (MeOH/DCM/diethyl ether), filtered and dried under high vacuum to give (S)-4-chloro-7-(quinuclidin-3-yl)-8,9-dihydro-[1,4]diazepino[6,7,1-hi]indazol-6(7H)-one hydrochloride as a yellow solid (359 mg, 31%): 1H NMR (500 MHz, D2O) δ 7.81 (s, 1H), 7.68 (s, 2H), 4.43-4.20 (m, 3H), 3.80-3.65 (m, 1H), 3.65-3.50 (m, 1H), 3.40-3.20 (m, 2H), 3.20-3.00 (m, 4H), 2.26 (s, 1H), 2.00-1.70 (m, 4H); MS (ESI+) m/z 331 (M+H).

Provenance & Evidence