Hydrochloric Acid → HCID 178479597, compound

Participants

Reaction Steps

4-(Quinuclidin-4-ylmethyl)-3,4-dihydropyrazolo[3,4,5-de]isoquinolin-5(1H)-one (468 mg, 1.58 mmol) from Step C above was dissolved in HCl (1.25 M in methanol) and concentrated under reduced pressure to give 4-(quinuclidin-4-ylmethyl)-3,4-dihydropyrazolo[3,4,5-de]isoquinolin-5(1H)-one hydrochloride as an off-white solid (305 mg, 58%): 1H NMR (500 MHz, CD3OD) δ 7.63-7.61 (m, 1H), 7.55-7.53 (m, 2H), 5.15 (s, 2H), 3.58 (s, 2H), 3.08 (t, J=8.0 Hz, 6H), 1.78 (t, J=8.0 Hz, 6H); MS (ESI+) m/z 297 (M+H).

Provenance & Evidence