HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 3-(4-Benzyloxy-phenyl)-1,1,1-trifluoro-propan-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Cesium fluoride | HCID 25953 | — |
| Reactant | (Trifluoromethyl)trimethylsilane | HCID 552549 | — |
| Reactant | Methyl 2-(4-benzyloxyphenyl)acetate | HCID 2756645 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 3-(4-Benzyloxy-phenyl)-1,1,1-trifluoro-propan-2-one | HCID 67387207 | — |
Reaction Steps
A mixture of (4-benzyloxy-phenyl)-acetic acid methyl ester (11.7 mmol, 3.0 g), trimethyl-trifluoromethyl-silane and cesium fluoride in THF may be stirred at room temperature for 2 h. Hydrochloride may be added upon consumption of ester as indicated by TLC. The mixture may be stirred further at room temperature until the intermediate disappears as indicated by TLC to provide 3-(4-benzyloxy-phenyl)-1,1,1-trifluoro-propan-2-one.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09045461B2 |
| Source dataset | uspto-grants-2015_06 |
| ORD ID | ord-635bf373a0984232bca548a6e1588bee |
| Source note | uspto-grants-2015_06 |