Hydrochloric Acid → HCID 67372253, compound

Participants

Reaction Steps

3-Butyl-4-(4-cyclohexyloxy-phenyl)-6-(4,4-difluoro-1-methyl-piperidin-3-ylmethoxy)-pyridazine was dissolved in 4.0 M HCl in dioxane (2 mL) and evaporated the solvent to provide the title compound (59 mg). LCMS: m/z 475 [M+1]. 1H NMR (400 MHz, CD3OD) δ 7.29 (2H, d), 7.04 (2H, d), 6.97 (1H, s), 4.80 (1H, dd), 4.48-4.36 (2H, m), 3.16-3.06 (1H, m), 2.92-2.86 (3H, m), 2.76-2.60 (1H, m), 2.48-2.32 (5H, m), 2.16-2.04 (2H, m), 2.02-1.98 (2H, m), 1.82-1.78 (2H, m), 1.62-1.20 (10H, m), 0.79 (3H, t).

Provenance & Evidence