Hydrochloric Acid → HCID 67373638, compound

Participants

Reaction Steps

To a solution of 4-[6-butyl-5-(4-cyclohexyloxy-phenyl)-4-trifluoromethyl-pyridazin-3-yloxy]-piperidine-1-carboxylic acid tert-butyl ester (0.294 mmol, 0.17 g) in DCM (1 mL) was added 4 N HCl in dioxane (0.5 mL) and the reaction was stirred for 1 hour. The solvents were removed with reduced pressure and the salt was triturated with diethyl ether and filtered to give 3-butyl-4-(4-cyclohexyloxy-phenyl)-6-(piperidin-4-yloxy)-5-trifluoromethyl-pyridazine dihydrochloride (0.12 g).

Provenance & Evidence