HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 6-Butyl-5-(4-cyclohexyloxy-phenyl)-pyridazine-3-carboxylic acid ((R)-1-ethyl-pyrrolidin-2-ylmethyl)-amide dihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 6-butyl-5-(4-cyclohexyloxy-phenyl)-pyridazine-3-carboxylic acid ((R)-1-ethyl-pyrrolidin-2-ylmethyl)-amide | HCID 58438415 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 6-Butyl-5-(4-cyclohexyloxy-phenyl)-pyridazine-3-carboxylic acid ((R)-1-ethyl-pyrrolidin-2-ylmethyl)-amide dihydrochloride | HCID 67374731 | — |
Reaction Steps
The amide was treated with 2 mL of 4.0 M HCl in dioxane solution in 2 mL of DCM for 1 h to provide the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09045461B2 |
| Source dataset | uspto-grants-2015_06 |
| ORD ID | ord-b149ddaa2cc84c4ab65680bce5366ef2 |
| Source note | uspto-grants-2015_06 |