HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → Tert-butyl 4-carbamoyl-4-fluoropiperidine-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Ethyl N-Boc-4-fluoropiperidine-4-carboxylate | HCID 21306965 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Tert-butyl 4-carbamoyl-4-fluoropiperidine-1-carboxylate | HCID 46942209 | — |
Reaction Steps
4-Fluoro-piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester (1.8 mmol, 0.5 g) was taken in 7M NH3 in MeOH (5 mL) and stirred at room temperature for 12 h in a sealed vial. All volatiles were removed under reduced pressure to provide 4-carbamoyl-4-fluoro-piperidine-1-carboxylic acid tert-butyl ester as white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09045461B2 |
| Source dataset | uspto-grants-2015_06 |
| ORD ID | ord-530aa9c097574c7f8544cd7be928f520 |
| Source note | uspto-grants-2015_06 |