1,2-Dichloroethane → HCID 131732923, compound

Participants

Reaction Steps

3-(1-naphtyl)-L-alanine-Val-OAllyl (0.394 g, 1.11 mmol) was solvated in CH2Cl2 (1.5 mL) and DMF (3 ml) followed addition of Z-Asp(OtBu)-OH (0.369 g, 1.03 eq), DMAP (14.8 mg, 0.11 eq) and 4-methylmorpholine (0.125 ml, 1.02 eq), then EDC (0.221 g, 1.04 eq). The vial was rinsed with 0.5 ml of dichloromethane. The mixture was stirred for 2 hours at room temperature. Then it was extracted using CH2Cl2/brine. The organic layer was dried over MgSO4, filtered off and concentrated. The obtained residue was purified on silica using a gradient EtOAc/Hex (0 to 80%) to get 0.516 g of the desired compound.

Provenance & Evidence