Morpholine → HCID 131732924, compound

Participants

Reaction Steps

Cbz-Asp(O-tBu)-3-(1-naphtyl)-L-alanine-Val-OAllyl (0.312 g, 0.47 mmol) was dissolved in THF (13 mL) and rotary evaporated to dryness, the sample was then redissolved in THF (13 mL) and vacuum aspirated (3*1 min of aspiration), followed by replacement of the atmosphere with Argon. Pd(PPh3)4 (0.060 g, 0.11 eq) was added in one shot, the flask was then evacued with Argon. Morpholine (0.267 mL, 4.42 eq) was added and the flask covered with a tin foil. The mixture was kept under stirring for 3 days under Argon. The sample was evaporated to dryness and the obtained residue was subjected to purification on C18 using a gradient of MeOH/solution of H2O at pH=3.5 (10 to 100%) to get 0.18 g of the desired compound.

Provenance & Evidence