Hydrochloride methanol → HCID 67320757, compound

HRID 2169064Notes

Reaction equation

[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[C:12]([CH2:13][CH2:14][CH2:15][CH2:16][O:17][CH3:18])=[C:11]([C:19]([N:21]([CH2:37][CH:38]([CH3:40])[CH3:39])[C@H:22]2[CH2:27][C@@H:26]([CH2:28][OH:29])[CH2:25][N:24](C(OC(C)(C)C)=O)[CH2:23]2)=[O:20])[N:10]=[N:9]1.[ClH:41].CO>>[ClH:41].[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[C:12]([CH2:13][CH2:14][CH2:15][CH2:16][O:17][CH3:18])=[C:11]([C:19]([N:21]([C@H:22]2[CH2:27][C@@H:26]([CH2:28][OH:29])[CH2:25][NH:24][CH2:23]2)[CH2:37][CH:38]([CH3:40])[CH3:39])=[O:20])[N:10]=[N:9]1

Participants

Reactant 2

HCID 21893726Hydrochloride methanol

HCID 58355139HCID 58355139, compound

Product 1

HCID 67320757HCID 67320757, compound

Procedure

tert-Butyl (3S,5R)-3-[{[1-(2-fluorophenyl)-5-(4-methoxybutyl)-1H-1,2,3-triazol-4-yl]carbonyl}(2-methylpropyl)amino]-5-(hydroxymethyl)piperidine-1-carboxylate (400 mg) was dissolved in 10% hydrogen chloride-methanol (4 ml), and the mixture was stirred at room temperature for 18 hr. The reaction mixture was concentrated to give the object product (334 mg).

Workup

concentrationThe reaction mixture was concentrated

Sources & evidence

ORD record: ord-6777eca904fd4774a037f65b3396666d
Source dataset: uspto-grants-2015_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09045436B2

Reaction notes

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