Methyl N-(triethylammoniosulfonyl)carbamate → (S)-tert-Butyl 4-(1-cyano-2-(4'-cyanobiphenyl-4-yl)ethylcarbamoyl)tetrahydro-2H-pyran-4-ylcarbamate

Participants

Reaction Steps

(S)-tert-Butyl 4-(1-amino-3-(4′-cyanobiphenyl-4-yl)-1-oxopropan-2-ylcarbamoyl)tetrahydro-2H-pyran-4-ylcarbamate (Example 3, step (iv), 0.70 g) in dichloromethane (15 mL) was treated with Burgess' reagent (0.356 g) and the mixture was stirred at room temperature for 6 h. Additional Burgess' reagent (0.15 g) was added and the reaction was stirred overnight. The mixture was absorbed onto silica and purified by chromatography on silica eluting with 33% ethyl acetate in isohexane and then 100% ethyl acetate to afford the sub-titled compound as a solid (0.420 g).

Provenance & Evidence