Hydroxylamine → HCID 178510758, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of (2′-chloro-biphenyl-2-yl)-acetonitrile (15) (2 g, 8.78 mmol) in ethanol (20 mL) was added aqueous hydroxylamine (50%) (1.16 g, 17.8). The mixture was heated to 60° C. for 16 h. After completion of the reaction, the reaction mixture was evaporated, extracted with ethyl acetate and concentrated to get 2-(2′-chloro-biphenyl-2-yl)-N-hydroxy-acetamidine (16) (2.1 g, 91.7%) as an off-white solid which was directly used in the next step.

Provenance & Evidence