反应详情

To 10 mL acetic anhydride was added 2-(2′-chloro-biphenyl-2-yl)-N-hydroxy-acetamidine (16) (2 g, 7.692 mmol). The mixture was stirred for 6 h at room temperature. After completion of the reaction, water was added, the mixture was extracted with ethyl acetate, evaporated, dried and purified using a CombiFlash column using 25% ethyl acetate in hexane to get 2-(2′-chloro-biphenyl-2-yl)-N-acetyl-acetamidine (17) (2 g, 85.88%) as an off-white solid.

1. additionwas added
2. extractionthe mixture was extracted with ethyl acetate
3. customevaporated
4. customdried
5. custompurified