反应详情

To the solution of 2-(2′-chloro-biphenyl-2-yl)-N-acetyl-acetamidine (17) (2 g, 6.623 mmol) in methanol (10 mL) was added 200 mg 10% Pd—C. The mixture was hydrogenated by balloon pressure at room temperature for 18 h. After completion of the reaction, the mixture was filtered and evaporated to afford 2-biphenyl-2-yl-acetamidine acetic acid salt (5-01) (1.4 g, 78.4%) as a white solid.

1. customAfter completion of the reaction
2. filtrationthe mixture was filtered
3. customevaporated