HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-(2-(tert-Butyldimethylsilyloxy)ethyl)methylamine → HCID 178484772, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-(2-(tert-Butyldimethylsilyloxy)ethyl)methylamine | HCID 16203640 | — |
| Reactant | HCID 178484773 | HCID 178484773 | — |
| Reactant | 2-[[2-(2-chlorophenyl)phenyl]methyl]-4-oxo-5-phenylmethoxy-1H-pyrimidine-6-carboxylic acid | HCID 178524877 | — |
| Product | HCID 178484772 | HCID 178484772 | 48.1% |
Reaction Steps
5-Benzyloxy-2-(2′-chloro-biphenyl-2-ylmethyl)-6-hydroxypyrimidine-4-carboxylic acid [2-(tert-butyl-dimethylsilanyloxy)-ethyl]-methyl-amide (9-02) (2 g, 48.09%) was synthesized as a yellow liquid from 5-benzyloxy-2-(2′-chloro-biphenyl-2-ylmethyl)-6-hydroxypyrimidine-4-carboxylic acid (7-02) (3 g, 6.72 mmol) and [2-(tert-butyl-dimethylsilanyloxy)-ethyl]-methyl-amine (8-a) (1.39 g, 7.399 mmol) following the procedure as described for 5-benzyloxy-2-biphenyl-2-ylmethyl-6-hydroxypyrimidine-4-carboxylic acid [2-(tert-butyl-dimethylsilanyloxy)-ethyl]-methyl-amide (9-01).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09045486B2 |
| Source dataset | uspto-grants-2015_06 |
| ORD ID | ord-f9b897efe457447d8c1f996c580bf937 |
| Source note | uspto-grants-2015_06 |