HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-(2-((tert-butyldimethylsilyl)oxy)ethyl)propan-2-amine → HCID 178457483, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-(2-((tert-butyldimethylsilyl)oxy)ethyl)propan-2-amine | HCID 57917054 | — |
| Reactant | HCID 178484773 | HCID 178484773 | — |
| Reactant | 2-[[2-(2-chlorophenyl)phenyl]methyl]-4-oxo-5-phenylmethoxy-1H-pyrimidine-6-carboxylic acid | HCID 178524877 | — |
| Product | HCID 178457483 | HCID 178457483 | 63.1% |
Reaction Steps
5-Benzyloxy-2-(2′-chloro-biphenyl-2-ylmethyl)-6-hydroxypyrimidine-4-carboxylic acid [2-(tert-butyl-dimethylsilanyloxy)-ethyl]-isopropylamide (9-04) (2.74 g, 63.03%) was synthesized as a dark liquid from 5-benzyloxy-2-(2′-chloro-biphenyl-2-ylmethyl)-6-hydroxypyrimidine-4-carboxylic acid (7-02) (3 g, 6.72 mmol) and [2-(tert-butyl-dimethylsilanyloxy)-ethyl]-isopropyl amine (8-b) (1.6 g, 7.399 mmol) following the procedure as described for 5-benzyloxy-2-biphenyl-2-ylmethyl-6-hydroxypyrimidine-4-carboxylic acid [2-(tert-butyl-dimethylsilanyloxy)-ethyl]-methyl-amide (9-01).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09045486B2 |
| Source dataset | uspto-grants-2015_06 |
| ORD ID | ord-953c91a35114486b9f46b340cf4b6ed7 |
| Source note | uspto-grants-2015_06 |