HRID2169147

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)N1CCN2C(Cc3ccccc3-c3ccccc3Cl)=NC(O)C(OCc3ccccc3)=C2C1=O

HCID86725800

未命名化合物

结构：CN1CCn2c(Cc3ccccc3-c3ccccc3)nc(=O)c(O)c2C1=O

HCID86725801

未命名化合物

PRODUCTS

生成物

结构：CC(C)N1CCn2c(Cc3ccccc3-c3ccccc3Cl)nc(=O)c(O)c2C1=O

HCID86725804

未命名化合物

收率 37.07%

PROCEDURE

实验过程

6-(2′-Chloro-biphenyl-2-ylmethyl)-9-hydroxy-2-isopropyl-3,4-dihydro-2H-pyrazino[1,2-c]pyrimidine-1,8-dione (12-04) (107 mg, 37.07%) was synthesized as an off-white solid from 9-benzyloxy-6-(2′-chloro-biphenyl-2-ylmethyl)-8-hydroxy-2-isopropyl-3,4-dihydro-2H,8H-pyrazino[1,2-c]pyrimidin-1-one (11-04) (350 mg, 0.682 mmol) following the procedure as described for 6-biphenyl-2-ylmethyl-9-hydroxy-2-methyl-3,4-dihydro-2H-pyrazino[1,2-c]pyrimidine-1,8-dione (12-01).