Ethanolamine → Oxazolidine, 2-methyl-2-(trifluoromethyl)-

Temperature

-30 °C

A solution of 2-aminoethanol (10.15 g, 10.0 ml, 166 mmol, Eq: 1.00) in dichloromethane (250 ml) was cooled to −30° C. and stirred while 1,1,1-trifluoropropan-2-one (20.1 g, 16.1 ml, 179 mmol, Eq: 1.08), followed by molecular sieves (4 Å, powder <5 micron, activated; 20.0 g, 166 mmol, Eq: 1.00) were added. The mixture was stirred at −30° C. for 3 h and then allowed to warm to room temperature and left stirring for overnight. The mixture was filtered, washed with dichloromethane, and concentrated to obtain 2-methyl-2-(trifluoromethyl)oxazolidine (39) (oil, 15.60 g, 101 mmol, 60.5% yield).

1. additionwere added
2. temperatureto warm to room temperature
3. waitleft
4. stirringstirring for overnight
5. filtrationThe mixture was filtered
6. washwashed with dichloromethane
7. concentrationconcentrated

ORD record

ord-f0181f17c1d0418ca29c1159c57a4a8e

Source dataset

uspto-grants-2015_06

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US09045486B2