Methyl N-(triethylammoniosulfonyl)carbamate → (S)-tert-Butyl 4-(2-(4'-(azetidin-1-ylsulfonyl)biphenyl-4-yl)-1-cyanoethylcarbamoyl)tetrahydro-2H-pyran-4-ylcarbamate

Beteiligte Stoffe

Reaktionsschritte

(S)-tert-Butyl 4-(1-amino-3-(4′-(azetidin-1-ylsulfonyl)biphenyl-4-yl)-1-oxopropan-2-ylcarbamoyl)tetrahydro-2H-pyran-4-ylcarbamate (Example 7, step (i), 309 mg) in dichloromethane (8 mL) was treated with Burgess' reagent (251 mg) and the mixture was stirred at room temperature for 18 h. The solvent was partially evaporated and then purified by chromatography on silica using diethyl ether and then 1:1 ethyl acetate/isohexane as eluent to yield a white solid (222 mg).

Herkunft & Nachweise