HRID2169223

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)(C)OC(=O)c1nc(Cc2ccccc2Br)nc(O)c1OCc1ccccc1

HCID178450816

未命名化合物

结构：O=C(O)c1nc(Cc2cccc(Cl)c2Cl)nc(O)c1OCc1ccccc1

HCID178524879

未命名化合物

PRODUCTS

生成物

结构：O=C(O)c1nc(Cc2ccccc2Br)nc(O)c1OCc1ccccc1

HCID178524876

未命名化合物

收率 68%

PROCEDURE

实验过程

5-Benzyloxy-2-(2-bromobenzyl)-6-hydroxypyrimidine-4-carboxylic acid (149) (16.5 g, 68%) as a brown solid was synthesized from 5-benzyloxy-2-(2-bromobenzyl)-6-hydroxypyrimidine-4-carboxylic acid tert-butyl ester (148) (30 g, 63.69 mmol) following the procedure as described for 5-benzyloxy-2-(2,3-dichlorobenzyl)-6-hydroxypyrimidine-4-carboxylic acid (131).