1-Cyclohexenylboronic acid → HCID 178457450, compound

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Reaction Steps

5-Benzyloxy-2-(2-cyclohex-1-enyl-benzyl)-6-hydroxypyrimidine-4-carboxylic acid (2-hydroxyethyl)-isopropylamide (155) (210 mg, 41.9%) as a colorless sticky liquid was synthesized from 5-benzyloxy-2-(2-bromobenzyl)-6-hydroxypyrimidine-4-carboxylic acid (2-hydroxyethyl)-isopropylamide (151) (500 mg, 0.999 mmol) and cyclohexene boronic acid (188.84 mg, 1.49 mmol) following the procedure as described for 5-benzyloxy-6-hydroxy-2-(4-methoxy-biphenyl-2-ylmethyl)-pyrimidine-4-carboxylic acid tert-butyl ester (139).

Provenance & Evidence