HRID2169228

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)N1CCn2c(Cc3cccc(Cl)c3Cl)nc(=O)c(OCc3ccccc3)c2C1=O

HCID86725868

未命名化合物

结构：CC(C)N(CCO)C(=O)c1nc(Cc2ccccc2C2=CCCCC2)nc(O)c1OCc1ccccc1

HCID178457450

未命名化合物

PRODUCTS

生成物

结构：CC(C)N1CCn2c(Cc3ccccc3C3=CCCCC3)nc(=O)c(OCc3ccccc3)c2C1=O

HCID86725876

未命名化合物

收率 44.2%

PROCEDURE

实验过程

9-Benzyloxy-6-(2-cyclohex-1-enyl-benzyl)-2-isopropyl-3,4-dihydro-2H-pyrazino[1,2-c]pyrimidine-1,8-dione (156) (42.5 mg, 44.15%) as an off-white solid was synthesized from 5-benzyloxy-2-(2-cyclohex-1-enyl-benzyl)-6-hydroxypyrimidine-4-carboxylic acid (2-hydroxyethyl)-isopropylamide (155) (100 mg, 0.199 mmol) following the procedure as described for 9-benzyloxy-6-(2,3-dichlorobenzyl)-2-isopropyl-3,4-dihydro-2H-pyrazino[1,2-c]pyrimidine-1,8-dione (134).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-639efe4dae2b440fac7907c3db369d65
来源数据集: uspto-grants-2015_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09045486B2
来源说明: uspto-grants-2015_06

反应 SMILES

O[CH2:2][CH2:3][N:4]([CH:35]([CH3:37])[CH3:36])[C:5]([C:7]1[C:12]([O:13][CH2:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[C:11]([OH:21])[N:10]=[C:9]([CH2:22][C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=2[C:29]2[CH2:34][CH2:33][CH2:32][CH2:31][CH:30]=2)[N:8]=1)=[O:6].C(OC1C(=O)N=C(CC2C=CC=C(Cl)C=2Cl)N2CCN(C(C)C)C(=O)C=12)C1C=CC=CC=1>>[CH2:14]([O:13][C:12]1[C:11](=[O:21])[N:10]=[C:9]([CH2:22][C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=2[C:29]2[CH2:34][CH2:33][CH2:32][CH2:31][CH:30]=2)[N:8]2[CH2:2][CH2:3][N:4]([CH:35]([CH3:37])[CH3:36])[C:5](=[O:6])[C:7]=12)[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1