9-Benzyloxy-6-[[2-(3,4-difluorophenyl)phenyl]methyl]-2-isopropyl-3,4-dihydropyrazino[1,2-c]pyrimidine-1,8-dione → 6-[[2-(3,4-Difluorophenyl)phenyl]methyl]-9-hydroxy-2-isopropyl-3,4-dihydropyrazino-[1,2-c]pyrimidine-1,8-dione

Participants

Reaction Steps

9-Benzyloxy-6-[[2-(3,4-difluorophenyl)phenyl]methyl]-2-isopropyl-3,4-dihydropyrazino[1,2-c]pyrimidine-1,8-dione (170) (160 mg) in methanol (20 ml) was hydrogenated over 10% Pd/C (20.6 mg) at room temperature and at atmospheric pressure for 2 h. The catalyst was filtered off, the filtrate was concentrated in vacuo to give the desired product as a light yellow foam (112 mg).

Provenance & Evidence