反应详情

To a stirred solution of 1-phenyl-cyclohexanecarbaldehyde (250) (16.4 g, 87.1 mmol) in methanol (200.0 mL) was added NaBH4 (6.62 g, 174.2 mmol) portion-wise at 0° C. The reaction mixture was then stirred at room temperature for 2 h. After completion of the reaction, the solvent was concentrated and the crude product was extracted with ethyl acetate. The organic layer was then washed with water and brine and dried over sodium sulfate and concentrated under reduced pressure to get (1-phenyl-cyclohexyl)-methanol (251) (15.2 g, 91.7%) as a white solid which was sufficiently pure to be used for the next step.

1. customAfter completion of the reaction
2. concentrationthe solvent was concentrated
3. extractionthe crude product was extracted with ethyl acetate
4. washThe organic layer was then washed with water and brine
5. dry with materialdried over sodium sulfate
6. concentrationconcentrated under reduced pressure