Methyl N-(triethylammoniosulfonyl)carbamate → (S)-tert-Butyl 4-(1-cyano-2-(4-(4-methyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)phenyl)ethylcarbamoyl)tetrahydro-2H-pyran-4-ylcarbamate

Beteiligte Stoffe

Reaktionsschritte

(S)-tert-Butyl 4-(1-amino-3-(4-(4-methyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)phenyl)-1-oxopropan-2-ylcarbamoyl)tetrahydro-2H-pyran-4-ylcarbamate (Example 10, step (iii), 155 mg) in dichloromethane (8 mL) was stirred at room temperature for 18 h with Burgess' reagent (134 mg). The solvent was partially evaporated and the mixture was absorbed onto silica for purification on a silica column using ethyl acetate/isohexane 1:1 as eluent to yield the sub-titled compound as a solid (156 mg).

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