反应详情

(S)-tert-Butyl 4-(1-amino-3-(4-(3-(3-methoxypropyl)-2-oxo-2,3-dihydrobenzo[d]oxazol-5-yl)phenyl)-1-oxopropan-2-ylcarbamoyl)tetrahydro-2H-pyran-4-ylcarbamate (Example 11, step (iii), 151 mg) in dichloromethane (10 mL) was treated with Burgess' reagent (121 mg) and the mixture was stirred for 18 h at room temperature. The solvent was partially evaporated and the mixture was purified by chromatography on silica eluting with ethyl acetate/isohexane (1:1) to yield the sub-titled compound (137 mg).

1. customThe solvent was partially evaporated
2. customthe mixture was purified by chromatography on silica eluting with ethyl acetate/isohexane (1:1)