2-cyclopropyl-9-hydroxy-6-(1-phenyl-cyclopentylmethyl)-3,4-dihydro-2H-pyrazino[1,2-c]pyrimidine-1,8-dione → 2-(2,2-Dimethyl-propyl)-9-hydroxy-6-(1-phenyl-cyclopentylmethyl)-3,4-dihydro-2H-pyrazino[1,2-c]pyrimidine-1,8-dione

Participants

Reaction Steps

This compound was prepared following the same method as described for 2-cyclopropyl-9-hydroxy-6-(1-phenyl-cyclopentylmethyl)-3,4-dihydro-2H-pyrazino[1,2-c]pyrimidine-1,8-dione (287) from 9-benzyloxy-2-(2,2-dimethyl-propyl)-6-(1-phenyl-cyclopentyl methyl)-3,4-dihydro-2 H-pyrazino[1,2-c]pyrimidine-1,8-dione (302) (120 mg, 0.24 mmol). The product was obtained as a white solid (30 mg, 30.5%).

Provenance & Evidence