Methyl N-(triethylammoniosulfonyl)carbamate → HCID 59568545, compound

Participants

Reaction Steps

(S)-tert-Butyl 4-(1-amino-3-(3′,4′-difluorobiphenyl-4-yl)-1-oxopropan-2-ylcarbamoyl)tetrahydro-2H-pyran-4-ylcarbamate (Example 13, step (i), 305 mg) in dichloromethane (10 mL) was treated with Burgess' reagent (289 mg) and the mixture was stirred at room temperature for 18 h. The solvent was partially evaporated and the residue was purified by chromatography on silica eluting with ethyl acetate/isohexane (1:1) to yield the sub-titled compound (239 mg).

Provenance & Evidence