Methyl N-(triethylammoniosulfonyl)carbamate → (S)-tert-Butyl 4-(1-cyano-2-(4-iodophenyl)ethylcarbamoyl)tetrahydro-2H-pyran-4-ylcarbamate

Participants

Reaction Steps

(S)-tert-Butyl 4-(1-amino-3-(4-iodophenyl)-1-oxopropan-2-ylcarbamoyl)tetrahydro-2H-pyran-4-ylcarbamate (Example 1, step (iii), 0.610 g) in dichloromethane (15 mL) was treated with Burgess' reagent (0.365 g) and the mixture was stirred at room temperature for 2 days. The reaction mixture was absorbed onto silica and purified by chromatography on silica eluting with 25% ethyl acetate in isohexane, then 50% ethyl acetate in isohexane to afford the sub-titled compounds (0.402 g) as white crystals.

Provenance & Evidence