N-(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)cyclopropanamine → HCID 178455269, compound

Participants

Reaction Steps

This compound was prepared following the same method as described for 5-benzyloxy-6-hydroxy-2-(1-naphthalen-1-yl-cyclopentylmethyl)-pyrimidine-4-carboxylic acid [2-(tert-butyl-dimethylsilanyloxy)-ethyl]-methyl-amide (350) from 5-benzyloxy-6-hydroxy-2-(1-naphthalen-1-yl-cyclopentylmethyl)-pyrimidine-4-carboxylic acid (345) (250 mg, 0.55 mmol) and [2-(tert-butyl-dimethylsilanyloxy)-ethyl]-cyclopropyl-amine (8d) (177 mg, 0.83 mmol). The yield was 279 mg, 78% (white sticky mass).

Provenance & Evidence