反应详情

This compound was prepared following the same method as described for pure 9-benzyloxy-2-cyclopropyl-6-(1-naphthalen-1-yl-cyclopentylmethyl)-3,4-dihydro-2H-pyrazino[1,2-c]pyrimidine-1,8-dione (356) from 5-benzyloxy-6-hydroxy-2-(1-naphthalen-1-yl-cyclopentylmethyl)-pyrimidine-4-carboxylic acid (2-hydroxyethyl)-(tetrahydro-pyran-4-yl)-amide (367) (110 mg, 0.2 mmol). Purification was done on silica gel (normal, 100-200 mesh) using 1% to 5% methanol in dichloromethane as gradient eluent. The yield was 96 mg, 90%, of a white solid.

1. customThis compound was prepared
2. customPurification