(1-(3,5-Bis(trifluoromethyl)phenyl)cyclopentyl)methanol → (1-(3,5-Bis(trifluoromethyl)phenyl)cyclopentyl)methyl methanesulfonate

HRID 2169487Notes

Reaction equation

HRID 2169487 reaction equation
[F:1][C:2]([F:21])([F:20])[C:3]1[CH:4]=[C:5]([C:13]2([CH2:18][OH:19])[CH2:17][CH2:16][CH2:15][CH2:14]2)[CH:6]=[C:7]([C:9]([F:12])([F:11])[F:10])[CH:8]=1.FC(F)(F)C1C=CC(C2(C[O:36][S:37]([CH3:40])(=O)=[O:38])CCCC2)=CC=1>>[CH3:40][S:37]([O:19][CH2:18][C:13]1([C:5]2[CH:4]=[C:3]([C:2]([F:20])([F:21])[F:1])[CH:8]=[C:7]([C:9]([F:10])([F:11])[F:12])[CH:6]=2)[CH2:17][CH2:16][CH2:15][CH2:14]1)(=[O:38])=[O:36]

Participants

3

Reactant 2

HCID 10335667(1-(3,5-Bis(trifluoromethyl)phenyl)cyclopentyl)methanolHCID 86725929Methanesulfonic acid 1-(4-trifluoromethyl-phenyl)-cyclopentylmethyl ester

Product 1

HCID 86726110(1-(3,5-Bis(trifluoromethyl)phenyl)cyclopentyl)methyl methanesulfonate

Procedure

(1-(3,5-bis(trifluoromethyl)phenyl)cyclopentyl)methyl methanesulfonate (458) was synthesized from ((1-(3,5-bis(trifluoromethyl)phenyl)cyclopentyl)methanol (457) following the procedure described for methanesulfonic acid 1-(4-trifluoromethyl-phenyl)-cyclopentylmethyl ester (240).

Sources & evidence

ORD record
ord-206e4baf01e04341874d724547386ebd
Source dataset
uspto-grants-2015_06
Patent number
US09045486B2

Reaction notes

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