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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2169491Generated: November 1, 2026

HCID 178457441, compound → HCID 178457445, compound

https://huagongshe.com/reaction/2169491

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHCID 178457441HCID 178457441—
ReactantHCID 178457481HCID 178457481—
ProductHCID 178457445HCID 178457445—

Reaction Steps

5-(Benzyloxy)-2-((1-(3,5-bis(trifluoromethyl)phenyl)cyclopentyl)methyl)-6-hydroxy-N-(2-hydroxyethyl)-N-isopropylpyrimidine-4-carboxamide (464) was synthesized form 5-(benzyloxy)-2-((1-(3,5-bis(trifluoromethyl)phenyl)cyclopentyl)methyl)-N-(2-((tert-butyldimethylsilyl)oxy)ethyl)-6-hydroxy-N-isopropylpyrimidine-4-carboxamide (463) following the procedure described 5-benzyloxy-2-[1-(4-trifluoromethyl-phenyl)-cyclopentylmethyl]-6-hydroxypyrimidine-4-carboxylic acid (2-hydroxyethyl)-isopropylamide (246).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09045486B2
Source datasetuspto-grants-2015_06
ORD IDord-bf3e4f815e7641f6be3afce2cc8ef8a6
Source noteuspto-grants-2015_06