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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2169494Generated: November 1, 2026

1,4-Dibromobutane → 1-(3-(Trifluoromethyl)phenyl)cyclopentanecarbonitrile

https://huagongshe.com/reaction/2169494

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1,4-DibromobutaneHCID 8056—
Reactantm-TrifluoromethylphenylacetonitrileHCID 75360—
Reactant1-(4-(Trifluoromethyl)phenyl)cyclopentanecarbonitrileHCID 21899624—
Product1-(3-(Trifluoromethyl)phenyl)cyclopentanecarbonitrileHCID 43119035—

Reaction Steps

1-(3-(Trifluoromethyl)phenyl)cyclopentanecarbonitrile (468) was synthesized from 2-(3-(trifluoromethyl)phenyl)acetonitrile (467) and 1,4-dibromobutane following the procedure described for 1-(4-trifluoromethyl-phenyl)-cyclopentanecarbonitrile (237).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09045486B2
Source datasetuspto-grants-2015_06
ORD IDord-de44d5736b3b473ca5844c42db8055cf
Source noteuspto-grants-2015_06