HRID2169502

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)N1CCn2c(CC3(c4ccc(C(F)(F)F)cc4)CCCC3)nc(=O)c(O)c2C1=O

HCID86725888

未命名化合物

结构：CC(C)N1CCn2c(CC3(c4cccc(C(F)(F)F)c4)CCCC3)nc(=O)c(OCc3ccccc3)c2C1=O

HCID86726124

未命名化合物

PRODUCTS

生成物

结构：CC(C)N1CCn2c(CC3(c4cccc(C(F)(F)F)c4)CCCC3)nc(=O)c(O)c2C1=O

HCID86726125

未命名化合物

PROCEDURE

实验过程

9-Hydroxy-2-isopropyl-6-((1-(3-(trifluoromethyl)phenyl)cyclopentyl)methyl)-3,4-dihydro-1H-pyrazino[1,2-c]pyrimidine-1,8(2H)-dione (479) was synthesized as a white solid from 9-(benzyloxy)-2-isopropyl-6-((1-(3-(trifluoromethyl)phenyl)cyclopentyl)methyl)-3,4-dihydro-1H-pyrazino[1,2-c]pyrimidine-1,8(2H)-dione (478) following the procedure described for 6-[1-(4-trifluoromethyl-phenyl)-cyclopentylmethyl]-9-hydroxy-2-isopropyl-3,4-dihydro-2H-pyrazino[1,2-c]pyrimidine-1,8-dione (248).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-4200ab02ad1143c183cda53d087f36a9
来源数据集: uspto-grants-2015_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09045486B2
来源说明: uspto-grants-2015_06

反应 SMILES

C([O:8][C:9]1[C:14](=[O:15])[N:13]=[C:12]([CH2:16][C:17]2([C:22]3[CH:27]=[CH:26][CH:25]=[C:24]([C:28]([F:31])([F:30])[F:29])[CH:23]=3)[CH2:21][CH2:20][CH2:19][CH2:18]2)[N:11]2[CH2:32][CH2:33][N:34]([CH:37]([CH3:39])[CH3:38])[C:35](=[O:36])[C:10]=12)C1C=CC=CC=1.OC1C(=O)N=C(CC2(C3C=CC(C(F)(F)F)=CC=3)CCCC2)N2CCN(C(C)C)C(=O)C=12>>[OH:8][C:9]1[C:14](=[O:15])[N:13]=[C:12]([CH2:16][C:17]2([C:22]3[CH:27]=[CH:26][CH:25]=[C:24]([C:28]([F:29])([F:30])[F:31])[CH:23]=3)[CH2:18][CH2:19][CH2:20][CH2:21]2)[N:11]2[CH2:32][CH2:33][N:34]([CH:37]([CH3:39])[CH3:38])[C:35](=[O:36])[C:10]=12