HRID2169509

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID86726129

未命名化合物

结构：CC(C)(C)OC(=O)c1nc(CC2(c3ccc(C(F)(F)F)cc3)CCCC2)nc(O)c1OCc1ccccc1

HCID178450810

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)OC(=O)c1nc(CC2(c3ccc(Cl)c(Cl)c3)CCCC2)nc(O)c1OCc1ccccc1

HCID178450812

未命名化合物

PROCEDURE

实验过程

tert-Butyl 5-(benzyloxy)-2-((1-(3,4-dichlorophenyl)cyclopentyl)methyl)-6-hydroxypyrimidine-4-carboxylate (487) was synthesized as a white solid from 2-(1-(3,4-dichlorophenyl)-cyclopentyl)-acetamidine hydrochloride (486) following the procedure described for 5-benzyloxy-2-[1-(4-trifluoromethyl-phenyl)-cyclopentylmethyl]-6-hydroxypyrimidine-4-carboxylic acid tert-butyl ester (243)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-6523a88837c945ecade9cdf8a6e3ee0a
来源数据集: uspto-grants-2015_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09045486B2
来源说明: uspto-grants-2015_06

反应 SMILES

Cl.[Cl:2][C:3]1[CH:4]=[C:5]([C:10]2([CH2:15][C:16]([NH2:18])=[NH:17])[CH2:14][CH2:13][CH2:12][CH2:11]2)[CH:6]=[CH:7][C:8]=1[Cl:9].[C:19]([O:23][C:24]([C:26]1[C:31]([O:32][CH2:33][C:34]2[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=2)=[C:30]([OH:40])N=C(CC2(C3C=CC(C(F)(F)F)=CC=3)CCCC2)N=1)=[O:25])([CH3:22])([CH3:21])[CH3:20]>>[CH2:33]([O:32][C:31]1[C:26]([C:24]([O:23][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:25])=[N:17][C:16]([CH2:15][C:10]2([C:5]3[CH:6]=[CH:7][C:8]([Cl:9])=[C:3]([Cl:2])[CH:4]=3)[CH2:14][CH2:13][CH2:12][CH2:11]2)=[N:18][C:30]=1[OH:40])[C:34]1[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=1