HRID2169527

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID21993563

未命名化合物

结构：CN(CCO[Si](C)(C)C(C)(C)C)C(=O)c1nc(CC2(c3cccc4ccccc34)CCCC2)nc(O)c1OCc1ccccc1

HCID178484768

未命名化合物

结构：O=C(O)c1nc(CC2(c3ccc(Cl)cc3)CCCC2)nc(O)c1OCc1ccccc1

HCID178524871

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)[Si](C)(C)OCCN(Cc1ccccc1)C(=O)c1nc(CC2(c3ccc(Cl)cc3)CCCC2)nc(O)c1OCc1ccccc1

HCID178455253

未命名化合物

PROCEDURE

实验过程

This compound was prepared by following the same method as described for 5-benzyloxy-6-hydroxy-2-(1-naphthalen-1-yl-cyclopentylmethyl)-pyrimidine-4-carboxylic acid [2-(tert-butyl-dimethylsilanyloxy)-ethyl]-methyl-amide (350) from 5-Benzyloxy-2-[1-(4-chlorophenyl)-cyclopentylmethyl]-6-hydroxypyrimidine-4-carboxylic acid (324) and benzyl-[2-(tert-butyl-dimethylsilanyloxy)-ethyl]-amine (8I).

WORKUP

后处理

customThis compound was prepared

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-db04fcd3628e43f297eead421866867a
来源数据集: uspto-grants-2015_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09045486B2
来源说明: uspto-grants-2015_06

反应 SMILES

[Si](OCCN(C)C(C1C(OCC2C=CC=CC=2)=C(O)N=C(CC2(C3C4C(=CC=CC=4)C=CC=3)CCCC2)N=1)=O)(C(C)(C)C)(C)C.[CH2:46]([O:53][C:54]1[C:55]([C:74]([OH:76])=O)=[N:56][C:57]([CH2:61][C:62]2([C:67]3[CH:72]=[CH:71][C:70]([Cl:73])=[CH:69][CH:68]=3)[CH2:66][CH2:65][CH2:64][CH2:63]2)=[N:58][C:59]=1[OH:60])[C:47]1[CH:52]=[CH:51][CH:50]=[CH:49][CH:48]=1.[CH2:77]([NH:84][CH2:85][CH2:86][O:87][Si:88]([C:91]([CH3:94])([CH3:93])[CH3:92])([CH3:90])[CH3:89])[C:78]1[CH:83]=[CH:82][CH:81]=[CH:80][CH:79]=1>>[CH2:77]([N:84]([CH2:85][CH2:86][O:87][Si:88]([C:91]([CH3:94])([CH3:93])[CH3:92])([CH3:89])[CH3:90])[C:74]([C:55]1[C:54]([O:53][CH2:46][C:47]2[CH:52]=[CH:51][CH:50]=[CH:49][CH:48]=2)=[C:59]([OH:60])[N:58]=[C:57]([CH2:61][C:62]2([C:67]3[CH:72]=[CH:71][C:70]([Cl:73])=[CH:69][CH:68]=3)[CH2:63][CH2:64][CH2:65][CH2:66]2)[N:56]=1)=[O:76])[C:78]1[CH:83]=[CH:82][CH:81]=[CH:80][CH:79]=1