Benzyl({2-[(tert-butyldimethylsilyl)oxy]ethyl})amine → HCID 178455253, compound

HRID 2169527Notes

Reaction equation

HRID 2169527 reaction equation
[Si](OCCN(C)C(C1C(OCC2C=CC=CC=2)=C(O)N=C(CC2(C3C4C(=CC=CC=4)C=CC=3)CCCC2)N=1)=O)(C(C)(C)C)(C)C.[CH2:46]([O:53][C:54]1[C:55]([C:74]([OH:76])=O)=[N:56][C:57]([CH2:61][C:62]2([C:67]3[CH:72]=[CH:71][C:70]([Cl:73])=[CH:69][CH:68]=3)[CH2:66][CH2:65][CH2:64][CH2:63]2)=[N:58][C:59]=1[OH:60])[C:47]1[CH:52]=[CH:51][CH:50]=[CH:49][CH:48]=1.[CH2:77]([NH:84][CH2:85][CH2:86][O:87][Si:88]([C:91]([CH3:94])([CH3:93])[CH3:92])([CH3:90])[CH3:89])[C:78]1[CH:83]=[CH:82][CH:81]=[CH:80][CH:79]=1>>[CH2:77]([N:84]([CH2:85][CH2:86][O:87][Si:88]([C:91]([CH3:94])([CH3:93])[CH3:92])([CH3:89])[CH3:90])[C:74]([C:55]1[C:54]([O:53][CH2:46][C:47]2[CH:52]=[CH:51][CH:50]=[CH:49][CH:48]=2)=[C:59]([OH:60])[N:58]=[C:57]([CH2:61][C:62]2([C:67]3[CH:72]=[CH:71][C:70]([Cl:73])=[CH:69][CH:68]=3)[CH2:63][CH2:64][CH2:65][CH2:66]2)[N:56]=1)=[O:76])[C:78]1[CH:83]=[CH:82][CH:81]=[CH:80][CH:79]=1

Participants

4

Reactant 3

HCID 21993563Benzyl({2-[(tert-butyldimethylsilyl)oxy]ethyl})amineHCID 178484768HCID 178484768, compoundHCID 178524871HCID 178524871, compound

Product 1

HCID 178455253HCID 178455253, compound

Procedure

This compound was prepared by following the same method as described for 5-benzyloxy-6-hydroxy-2-(1-naphthalen-1-yl-cyclopentylmethyl)-pyrimidine-4-carboxylic acid [2-(tert-butyl-dimethylsilanyloxy)-ethyl]-methyl-amide (350) from 5-Benzyloxy-2-[1-(4-chlorophenyl)-cyclopentylmethyl]-6-hydroxypyrimidine-4-carboxylic acid (324) and benzyl-[2-(tert-butyl-dimethylsilanyloxy)-ethyl]-amine (8I).

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-db04fcd3628e43f297eead421866867a
Source dataset
uspto-grants-2015_06
Patent number
US09045486B2

Reaction notes

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